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A Combination of Glucagon

Long-term adherence to dietary intervention such as Mediterranean diet and low carbohydrate diet may help to produce a sustainable weight loss, while the consumption of food or herbal products with antioxidant and anti-inflammatory properties synergizes the effect of GLP1 receptor agonist and improves the overall health.

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Glucagon-like peptide 1 ( GLP-1 ), a gastrointestinal peptide and central mediator of glucose metabolism, is secreted by L cells in the intestine in response to food intake. Postprandial secretion of GLP-1 is triggered by nutrient-sensing via transporters and G-protein-coupled receptors (GPCRs). GLP-1 secretion may be lower in adults with obesity/overweight (OW) or type 2 diabetes mellitus (T2DM ...

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Dietary impact on fasting and stimulated GLP

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The secretion of GLP-1 is partly mediated by nutrient binding to G-protein-coupled receptors (GPCRs) or by absorption via membrane transporters, which are expressed by enteroendocrine L cells in the gastrointestinal tract. Thus, postprandial GLP-1 secretion also has therapeutic potential. Adjusting the diet in a way that increases the interaction with these molecules could enhance GLP-1 ...

The central signaling pathways related to metabolism

Patients who used the GLP-1 receptor agonist exenatide displayed decreased neuronal responses to pictures of food measured by functional magnetic resonance imaging (fMRI) in parts of the brain ...

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