Human islets contain a subpopulation of glucagon
Our study shows that glucagon-like peptide-1 ( GLP-1 ) is secreted within human islets and may play an unexpectedly important paracrine role in islet physiology and pathophysiology. It is known that α cells within rodent and human pancreatic islets ...
Glucagon-like peptide 1 ( GLP-1 ) exerts many actions that improve glycemic control. GLP-1 stimulates glucose-stimulated insulin secretion and protects β cells , while its extrapancreatic effects include cardioprotection, reduction of hepatic glucose production, and regulation of satiety. Although an appealing antidiabetic drug candidate, the rapid degradation of GLP-1 by dipeptidyl peptidase 4 ...
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It is known that α cells within rodent and human pancreatic islets are capable of secreting GLP-1 , but little is known about the functional role that islet -derived GLP-1 plays in human islets .
Useful Notes on Role Of Glp-1 Analogs On Islet Cells
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Based on the results from in vitro and in vivo studies in humans and animal models, we describe the specific actions of GLP-1 analogs on the synthesis, processing, and secretion of insulin, islet morphology, and β cell proliferation and apoptosis.
In summary, our data suggest no direct role for CCK in stimulating insulin secretion and highlight the critical role of intra- islet GLP-1 signaling in the regulation of human β- cell function.
Additional Notes on Role Of Glp 1 Analogs On Islet Cells
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